Independent publications
31. Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles
Jeremy I. Ramsden, Bruna Zucoloto Da Costa, Rachel S. Heath, James R. Marshall, Sasha R. Derrington, Juan Mangas-Sanchez, Keith R. Mulholland, Sebastian C. Cosgrove*, Nicholas J. Turner
ACS Catal., 2024, 14, 14703
30. Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water
Alice J. C. Wahart, Liam N. D. Beardmore, Robert A. Field, Sebastian C. Cosgrove*, Gavin J. Miller
Org. Lett., 2024, 26, 6642
29. Accessing active fragments for drug discovery utilising nitroreductase biocatalysis
Lauren Holder, Eda Yuce, Gabriel Oriomah, Aimee-Page Jenkins, Jóhannes Reynisson, Anja Winter, Sebastian C. Cosgrove*
ChemBioChem, 2024, 25, e202400428
28. Future directions in flow biocatalysis: the impact of new technology on sustainability
Rebecca E. Ruscoe, Sebastian C. Cosgrove*
Curr. Opin. Green. Sustainable Chem., 2024, 49, 100954
27. Harnessing a biocatalyst to bioremediate the purification of alkylglycosides
Alice J. C. Wahart, Jonathan P. Dolan, Simon D. Anderson, Aisling Ní Cheallaigh, Jessica Staniland, Marcelo A. Lima, Mark A. Skidmore, Gavin J. Miller, Sebastian C. Cosgrove*
ChemBioChem, 2024, 25, e202300625
26. Realizing the Continuous Chemoenzymatic Synthesis of Anilines Using an Immobilized Nitroreductase
Sebastian C. Cosgrove*, Gavin J. Miller, Amin Bornadel, Beatriz Dominguez
ACS Sustainable Chem. Eng., 2023, 11, 8556
25. Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis
Jonathan P. Dolan, Sebastian C. Cosgrove*, Gavin J. Miller
JACS Au, 2023, 3, 47
24. Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues
Sebastian C. Cosgrove*, Gavin J. Miller
Expert Opin. Drug DIscovery, 2022, 17, 355
23. Reaching new biocatalytic reactivity using continuous flow reactors
Sebastian C. Cosgrove*, Ashley P. Mattey
Chem. Eur. J., 2022, 28, e202103607
22. Oxidase enzymes as sustainable oxidation catalysts
Alice J. C. Wahart, Jessica Staniland, Gavin J. Miller, Sebastian C. Cosgrove*
R. Soc. Open Sci., 2022, 9, 211572
Ashley P. Mattey, Grayson J. Ford, Joan Citoler, Christopher Baldwin, James R. Marshall, Ryan B. Palmer, Matthew Thompson, Nicholas J. Turner, Sebastian C. Cosgrove*, Sabine L. Flitsch
Angew. Chem. Int. Ed., 2021, 60, 18660 – Hot paper; back cover art
20. Biocatalysis in Flow for Drug Discovery
Itziar Peñafiel, Sebastian C. Cosgrove*
Flow Chemistry in Drug Discovery, ed. J. Alcazar, Springer, pp. 275-316
19. Is it time for biocatalysis in fragment-based drug discovery?
Jeremy I. Ramsden, Sebastian C. Cosgrove*, Nicholas J. Turner
Chem. Sci., 2020, 11, 11104
Postdoc publications
William Finnigan, Max Lubberink, Lorna J. Hepworth, Joan Citoler, Ashley P. Mattey, Grayson J. Ford, Jack Sangster, Sebastian C. Cosgrove, Bruna Zucoloto da Costa, Rachel S. Heath, Thomas W. Thorpe, Yuqi Yu, Sabine L. Flitsch, Nicholas J. Turner
ACS Catal., 2023, 13, 11771
17. One-Pot Chemoenzymatic Cascade for the Enantioselective C (1)-Allylation of Tetrahydroisoquinolines
Jack J. Sangster, Rebecca E. Ruscoe, Sebastian C. Cosgrove, Juan Mangas-Sánchez, Nicholas J. Turner
J. Am. Chem. Soc., 2023, 145, 4431
16. Application of Engineered Biocatalysts for the Synthesis of Active Pharmaceutical Ingredients (APIs)
Juan Mangas‐Sanchez, Sebastian C. Cosgrove, Nicholas J. Turner
Protein Engineering: Tools and Applications, ed. H. Zhao, Wiley, 2021, pp. 265-294
15. Biocatalytic Synthesis of Chiral Amines Using Oxidoreductases
Sebastian C. Cosgrove, Jeremy I. Ramsden, Juan Mangas‐Sanchez, Nicholas J. Turner
Methodologies in Amine Synthesis, ed. A. Ricci and L. Bernardi, Wiley, 2021, pp. 243–283
Aled D. Roberts, Karl A. P. Payne, Sebastian C. Cosgrove, Viranga Tilakaratna, Itziar Penafiel, William Finnigan, Nicholas J. Turner, Nigel S. Scrutton
Green Chem., 2021, 23, 4716
Sebastian C. Cosgrove, Matthew P. Thompson, Syed T. Ahmed, Fabio Parmeggiani, Nicholas J. Turner
Angew. Chem. Int. Ed., 2020, 59, 18156
12. Rapid model-based optimization of a two-enzyme system for continuous reductive amination in flow
William Finnigan, Joan Citoler, Sebastian C. Cosgrove, Nicholas J. Turner
Org. Process Res. Dev., 2020, 24, 1969
11. Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases
Juan Mangas-Sanchez, Mahima Sharma, Sebastian C. Cosgrove, Jeremy I. Ramsden, James R. Marshall, Thomas W. Thorpe, Ryan B. Palmer, Gideon Grogan, Nicholas J. Turner
Chem. Sci., 2020, 11, 5052
10. Natural heterogeneous catalysis with immobilised oxidase biocatalysts
Ashley P. Mattey, Jack J. Sangster, Jeremy I. Ramsden, Christopher Baldwin, William R. Birmingham, Rachel S. Heath, Antonio Angelastro, Nicholas J. Turner, Sebastian C. Cosgrove*, Sabine L. Flitsch
RSC Advs., 2020, 10, 19501
9. Enantioselective synthesis of chiral vicinal amino alcohols using amine dehydrogenases
Fei-Fei Chen, Sebastian C. Cosgrove, William R. Birmingham, Juan Mangas-Sanchez, Joan Citoler, Matthew P. Thompson, Gao-Wei Zheng, Jian-He Xu, Nicholas J. Turner
ACS Catal., 2019, 9, 11813
8. Biocatalytic oxidation in continuous flow for the generation of carbohydrate dialdehydes
Sebastian C. Cosgrove, Ashley P. Mattey, Michel Riese, Michael R. Chapman, William R. Birmingham, A. John Blacker, Nikil Kapur, Nicholas J. Turner, Sabine L. Flitsch
ACS Catal., 2019, 9, 11658
7. Biocatalysis using immobilized enzymes in continuous flow for the synthesis of fine chemicals
Matthew P. Thompson, Itziar Peñafiel, Sebastian C. Cosgrove, Nicholas J. Turner
Org. Process Res. Dev., 2019, 23, 9
Michael R. Chapman, Sebastian C. Cosgrove, Nicholas J. Turner, Nikil Kapur, A. John Blacker
Angew. Chem. Int. Ed., 2018, 57, 10535
Sebastian C. Cosgrove, Agata Brzezniak, Scott P. France, Jeremy I. Ramsden, Juan Mangas-Sanchez, Sarah L. Montgomery, Rachel S. Heath, Nicholas J. Turner
Methods in Enzymology, 2018, 608, 131-149
PhD publications
4. Synergistic chemo/biocatalytic synthesis of alkaloidal tetrahydroquinolines
Sebastian C. Cosgrove, Shahed Hussain, Nicholas J. Turner, Stephen P. Marsden
ACS Catal., 2018, 8, 5570
3. Continuous Flow for the Photochemical C‐H Amination of Arenes
Sebastian C. Cosgrove, Gayle E. Douglas, Steven A. Raw, Stephen P. Marsden
ChemPhotoChem, 2018, 2, 851
2. Radical-mediated direct C–H amination of arenes with secondary amines
Sebastian C. Cosgrove, John M. C. Plane, Stephen P. Marsden
Chem. Sci, 2018, 9, 6647
1. Synthesis and organogelating behaviour of amino acid-functionalised triphenylenes
Jonathan E. Meegan, Xiaofei Yang, Ratana Rungsirisakun, Sebastian C. Cosgrove, Richard J. Bushby, Amin Sadeghpour, Michael Rappolt, Rik Brydson, Richard J. Ansell
Soft Matter, 2017, 13, 5922